du.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • chicago-author-date
  • chicago-note-bibliography
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
SNP association studies in Alzheimer's disease highlight problems for complex disease analysis
Högskolan Dalarna, Akademin Hälsa och samhälle, Medicinsk vetenskap.
2001 (engelsk)Inngår i: Trends in Genetics, ISSN 0168-9479, Vol. 17, nr 7, s. 407-413Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Genetic linkage and association analyses are two distinct approaches to understanding the genetic etiology of complex disease. Association analysis has become particularly popular in recent times, but the true utility of the strategy remains uncertain. To try to gain better insight into the relevant issues, we have used genetic association analysis to explore the etiology of Alzheimer's disease. Our empirical findings supplement the theoretical debate, illustrating the general doubtfulness of previous positive findings and the limited ability of typical association studies based on candidate genes to discern true medium-sized signals from false positives. Improvements in genotyping technologies and increasing the number of SNPs tested, without sophisticated allowance for all other issues, could simply lead to an unmanageable overload of false-positive signals, themselves obscuring true disease associations

sted, utgiver, år, opplag, sider
2001. Vol. 17, nr 7, s. 407-413
Emneord [en]
association analysis; SNP; Alzheimer's disease; genetic variation; genetic linkage; disease association; genotyping
Identifikatorer
URN: urn:nbn:se:du-2298OAI: oai:dalea.du.se:2298DiVA, id: diva2:519704
Tilgjengelig fra: 2006-09-19 Laget: 2006-09-19 Sist oppdatert: 2012-04-24bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Søk i DiVA

Av forfatter/redaktør
Jobs, Magnus
Av organisasjonen

Søk utenfor DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric

urn-nbn
Totalt: 532 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • chicago-author-date
  • chicago-note-bibliography
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf