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Assay for screening for six antimalarial drugs and one metabolite using dried blood spot sampling, sequential extraction and ion-trap detection
Högskolan Dalarna, Akademin Utbildning och humaniora, Kemi.
Högskolan Dalarna, Akademin Utbildning och humaniora, Kemi.
2010 (ikkje fastsett***)Inngår i: Bioanalysis, ISSN 1757-6199, Vol. 2, nr 10, s. 1839-1847Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [un]

Background: More parasites are becoming resistant to antimalarial drugs, and in many areas a change in first-line drug treatment is necessary. The aim of the developed assay is to help determine drug use in these areas and also to be a complement to interviewing patients, which will increase reliability of surveys. Results: This assay detects quinine, mefloquine, sulfadoxine, pyrimethamine, lumefantrine, chloroquine and its metabolite desethylchloroquine in a 100-µl dried blood spot. Most of the drugs also have long half-lives that make them detectable at least 7 days after administration. The drugs are extracted from the dried blood spot with sequential extraction (due to the big differences in physicochemical properties), solid-phase extraction is used as sample clean-up and separation is performed with gradient-LC with MS ion-trap detection. Conclusion: Detection limits (S/N > 5:1) at 50 ng/ml or better were achieved for all drugs except lumefantrine (200 ng/ml), and thus can be used to determine patient compliance. A major advantage of using the ion-trap MS it that it will be possible to go back into the data and look for other drugs as needed

sted, utgiver, år, opplag, sider
Future Science Ltd , 2010. Vol. 2, nr 10, s. 1839-1847
Identifikatorer
URN: urn:nbn:se:du-5209OAI: oai:dalea.du.se:5209DiVA, id: diva2:520300
Tilgjengelig fra: 2011-01-17 Laget: 2011-01-17 Sist oppdatert: 2012-04-24bibliografisk kontrollert

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