du.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • chicago-author-date
  • chicago-note-bibliography
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Frontotemporal Dementia-amyotrophic Lateral Sclerosis Complex is Simulated by Neurodegeneration With Brain Iron Accumulation
Uppsala Univ, Dept Publ Hlth Geriatr, Uppsala 75185, Sweden.
Uppsala Univ, Dept Publ Hlth Geriatr, Uppsala 75185, Sweden.
Uppsala Univ, Dept Publ Hlth Geriatr, Uppsala 75185, Sweden.
Uppsala Univ, Dept Neurosci Clin Neurophysiol, Uppsala 75185, Sweden.
Vise andre og tillknytning
2009 (engelsk)Inngår i: Alzheimer Disease and Associated Disorders, ISSN 0893-0341, E-ISSN 1546-4156, Vol. 23, nr 3, s. 298-300Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

We describe a case of late onset neurodegeneration with brain iron accumulation (NBIA) presenting as frontotemporal dementia (FTD) with amyotrophic lateral sclerosis (ALS). A male patient presented at age 66 with change of personality: disinhibition, emotional blunting, and socially inappropriate behavior, coupled with dysarthria, dystonia, and corticospinal tract involvement. Magnetic resonance imaging showed general cortical atrophy, iron deposits in the globus pallidus, and the “eye of the tiger” sign. Neuropsychologic performance was globally reduced, especially executive functions. Fluorodeoxyglucose positron emission tomography showed hypometabolism predominantly in frontal and temporal areas. Repeated neurophysiologic examinations showed signs of chronic denervation. The patient was diagnosed with NBIA but fulfilled consensus criteria for FTD and had a clinical picture of ALS, without neurophysiologic confirmation. Our finding introduces NBIA as a possible cause of FTD and as a differential diagnosis of the FTD-ALS complex.

sted, utgiver, år, opplag, sider
2009. Vol. 23, nr 3, s. 298-300
Emneord [en]
neurodegeneration with brain iron accumulation; Hallervorden-Spatz disease; frontotemporal dementia; amyotrophic lateral sclerosis
HSV kategori
Identifikatorer
URN: urn:nbn:se:du-13164ISI: 000269909300020OAI: oai:DiVA.org:du-13164DiVA, id: diva2:655821
Tilgjengelig fra: 2013-10-14 Laget: 2013-10-14 Sist oppdatert: 2018-01-11bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Søk i DiVA

Av forfatter/redaktør
Skoglund, Lena
I samme tidsskrift
Alzheimer Disease and Associated Disorders

Søk utenfor DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric

urn-nbn
Totalt: 584 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • chicago-author-date
  • chicago-note-bibliography
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf