du.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • chicago-author-date
  • chicago-note-bibliography
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
An online simulator for Duodopa treatment and prediction of optimal individual dose to patients.
Högskolan Dalarna, Akademin Industri och samhälle, Datateknik.
2009 (Engelska)Självständigt arbete på avancerad nivå (masterexamen)Studentuppsats (Examensarbete)
Abstract [en]

The aim of this work was to develop an online simulator for levodoopa infusion in Parkinson’s disease based on a pharmacokinetic model. Using this simulator, optimal infusions setting were calculated, the relation between flow rate and morning bolus dose and usefulness for optimising the titration procedure of new infusion patients based on cased-based reasoning were investigated. Results show that the simulator was quite useful for simulating medication treatment and the relationship between optimal flow rate and morning dose seemed linear with some reasonable outliers. The prediction error revealed a tendency of simulator to under predict the actual flow rates and to over predict morning doses. At last, the simulator predicted well on each single occasion of majority of patients, but different flow rates and morning doses on different occasions of the same patient resulted in different matching parameters in database.

Ort, förlag, år, upplaga, sidor
Borlänge, 2009. , s. 46
Nyckelord [en]
Parkinson Disease, pharmacokinetic-pharmacodynamic model, levodopa, infusion, prediction error, case-based reasoning, dose titration
Identifikatorer
URN: urn:nbn:se:du-3794OAI: oai:dalea.du.se:3794DiVA, id: diva2:518613
Uppsök
teknik
Handledare
Tillgänglig från: 2009-03-12 Skapad: 2009-03-12 Senast uppdaterad: 2012-04-24Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Av organisationen
Datateknik

Sök vidare utanför DiVA

GoogleGoogle Scholar

urn-nbn

Altmetricpoäng

urn-nbn
Totalt: 60 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • chicago-author-date
  • chicago-note-bibliography
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf