du.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • chicago-author-date
  • chicago-note-bibliography
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
SNP association studies in Alzheimer's disease highlight problems for complex disease analysis
Högskolan Dalarna, Akademin Hälsa och samhälle, Medicinsk vetenskap.
2001 (Engelska)Ingår i: Trends in Genetics, ISSN 0168-9479, Vol. 17, nr 7, s. 407-413Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Genetic linkage and association analyses are two distinct approaches to understanding the genetic etiology of complex disease. Association analysis has become particularly popular in recent times, but the true utility of the strategy remains uncertain. To try to gain better insight into the relevant issues, we have used genetic association analysis to explore the etiology of Alzheimer's disease. Our empirical findings supplement the theoretical debate, illustrating the general doubtfulness of previous positive findings and the limited ability of typical association studies based on candidate genes to discern true medium-sized signals from false positives. Improvements in genotyping technologies and increasing the number of SNPs tested, without sophisticated allowance for all other issues, could simply lead to an unmanageable overload of false-positive signals, themselves obscuring true disease associations

Ort, förlag, år, upplaga, sidor
2001. Vol. 17, nr 7, s. 407-413
Nyckelord [en]
association analysis; SNP; Alzheimer's disease; genetic variation; genetic linkage; disease association; genotyping
Identifikatorer
URN: urn:nbn:se:du-2298OAI: oai:dalea.du.se:2298DiVA, id: diva2:519704
Tillgänglig från: 2006-09-19 Skapad: 2006-09-19 Senast uppdaterad: 2012-04-24Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Sök vidare i DiVA

Av författaren/redaktören
Jobs, Magnus
Av organisationen
Medicinsk vetenskap

Sök vidare utanför DiVA

GoogleGoogle Scholar

urn-nbn

Altmetricpoäng

urn-nbn
Totalt: 532 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • chicago-author-date
  • chicago-note-bibliography
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf