du.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • chicago-author-date
  • chicago-note-bibliography
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Associations between cathepsin B and inflammation markers in elderly males and females
Högskolan Dalarna, Akademin Utbildning, hälsa och samhälle, Medicinsk vetenskap.ORCID-id: 0000-0002-6933-4637
Visa övriga samt affilieringar
2015 (Engelska)Ingår i: Horizons in World Cardiovascular Research, Nova Science Publishers, Inc., 2015, Vol. 8, s. 157-164Kapitel i bok, del av antologi (Refereegranskat)
Resurstyp
Text
Abstract [en]

Background: The association between cathepsin B and inflammatory disorders is being increasingly recognized, but the underlying mechanism is less understood. The aim of the present study was to study the association between cathepsin B and different inflammation markers in a community-based cohort of elderly males and females.

Methods: Blood samples were collected from 729 individuals in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort at the age of 75 years. Cathepsin B and the inflammation markers CRP, Pentraxin 3, TNF receptor 1 and TNF receptor 2 were analyzed together with albumin, cholesterol, HDL-cholesterol, LDL-cholesterol, cholesterol, apolipoprotein A1, apolipoprotein B and triglycerides.

Results: Cathepsin B was significantly associated with TNF receptor 1 and 2 (P<0.001) but not with CRP and pentraxin 3. There were also significant associations with cholesterol, LDL and apolipoprotein B.

Conclusion: The type of inflammatory response is of importance for circulating cathepsin B. The association between cathepsin B and the cardiovascular risk markers cholesterol, LDL-cholesterol and apolipoprotein B could contribute to plaque destabilisation and ruptures by cathepsin B.

Ort, förlag, år, upplaga, sidor
Nova Science Publishers, Inc., 2015. Vol. 8, s. 157-164
Nationell ämneskategori
Klinisk medicin
Forskningsämne
Hälsa och välfärd
Identifikatorer
URN: urn:nbn:se:du-21204Scopus ID: 2-s2.0-84958851187ISBN: 978-163482582-5 (tryckt)ISBN: 978-163482551-1 (tryckt)OAI: oai:DiVA.org:du-21204DiVA, id: diva2:909050
Tillgänglig från: 2016-03-04 Skapad: 2016-03-04 Senast uppdaterad: 2016-03-04Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Scopus

Personposter BETA

Ärnlöv, Johan

Sök vidare i DiVA

Av författaren/redaktören
Ärnlöv, Johan
Av organisationen
Medicinsk vetenskap
Klinisk medicin

Sök vidare utanför DiVA

GoogleGoogle Scholar

isbn
urn-nbn

Altmetricpoäng

isbn
urn-nbn
Totalt: 461 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • chicago-author-date
  • chicago-note-bibliography
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf