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A new approach to evaluate stability of amodiaquine and its metabolite in blood and plasma
Högskolan Dalarna, Akademin Industri och samhälle, Kemiteknik.
Högskolan Dalarna, Akademin Industri och samhälle, Kemiteknik.
2006 (engelsk)Inngår i: Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, E-ISSN 1873-264X, Vol. 41, nr 1, s. 207-212Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

A stability study for amodiaquine (AQ) and desethylamodiaquine (AQm) in whole blood and plasma is reported. AQ, AQm and chloroquine (CQ) were simultaneously analysed and the ratios AQ/CQ and AQm/CQ were used to ensure correct interpretation of the stability results. CQ was stable in whole blood and plasma at all tested temperatures enabling it to be a stability marker in stability studies. Simultaneous analysis of compounds, of which at least one is already known to be stable, permits a within sample ratio to be used as a stability indicator, The new approach significantly reduced bias when compared to the traditional approach. AQ and AQm were stable in plasma at -86 degrees C and -20 degrees C for 35 days, at 4 degrees C for 14 days and at 22 degrees C for 1 day. AQ and AQm were stable in blood at -86 degrees C and 4 degrees C for 35 days, at -20 degrees C and 22 degrees C for 7 days and at 37 degrees C for 1 day.

sted, utgiver, år, opplag, sider
2006. Vol. 41, nr 1, s. 207-212
Emneord [en]
antimalarial; amoditiquine; chloroquine; desethylamodiaquine; liquid chromatography; solid-phase extraction; stability
HSV kategori
Identifikatorer
URN: urn:nbn:se:du-1619DOI: 10.1016/j.jpba.2005.10.018ISI: 000236655100028PubMedID: 16307860OAI: oai:dalea.du.se:1619DiVA, id: diva2:519574
Tilgjengelig fra: 2005-12-21 Laget: 2005-12-21 Sist oppdatert: 2017-12-07bibliografisk kontrollert

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