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Straightforward and rapid determination of sulfadoxine and sulfamethoxazole in capillary blood on sampling paper with liquid chromatography and UV detection
Högskolan Dalarna, Akademin Industri och samhälle, Kemiteknik.
Högskolan Dalarna, Akademin Industri och samhälle, Kemiteknik.
Högskolan Dalarna, Akademin Utbildning, hälsa och samhälle, Medicinsk vetenskap.
2009 (engelsk)Inngår i: Transactions of the Royal Society of Tropical Medicine and Hygiene, ISSN 0035-9203, E-ISSN 1878-3503, Vol. 103, nr 4, s. 371-376Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

A method for the determination of sulfadoxine and sulfamethoxazole in capillary blood on sampling paper has been developed and validated. The method is straightforward with minimal sample preparation, and is suitable for rural settings. Separation of sulfadoxine, sulfamethoxazole and internal standard was performed using a Purospher STAR RP-18 endcapped LC column (150 x 4.6 mm) with a mobile phase consisting of acetonitrile: sodium acetate buffer pH 5.2, 1=0.1 (1:2, v/v). For sulfadoxine, the within-day precision was 5.3% at 15 mu mol/l and 3.7% at 600 mu mol/l, while for sulfamethoxazole it was 5.7% at 15 mu mol/l and 3.8% at 600 mu mol/l. The tower limit of quantification was determined to 5 mu mol/l and precision was 5.5% and 5.0% for sulfadoxine and sulfamethoxazole, respectively.

sted, utgiver, år, opplag, sider
2009. Vol. 103, nr 4, s. 371-376
Emneord [en]
Malaria; Pneumonia; Sulfadoxine; Sulfamethoxazole; Chromatography; Dried blood spots
HSV kategori
Identifikatorer
URN: urn:nbn:se:du-2659DOI: 10.1016/j.trstmh.2008.11.031ISI: 000264976700009PubMedID: 19185326OAI: oai:dalea.du.se:2659DiVA, id: diva2:519794
Tilgjengelig fra: 2007-04-04 Laget: 2007-04-04 Sist oppdatert: 2017-12-07bibliografisk kontrollert

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