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Advanced maternal age increases the risk of very preterm birth, irrespective of parity: a population-based register study
Dalarna University, School of Education, Health and Social Studies, Medical Science.ORCID iD: 0000-0002-6923-7140
2017 (English)In: British Journal of Obstetrics and Gynecology, ISSN 1470-0328, E-ISSN 1471-0528, Vol. 124, no 8, 1235-1244 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To investigate whether advanced maternal age is associated with preterm birth, irrespective of parity.

DESIGN: Population-based registry study.

SETTING: Swedish Medical Birth Register.

POPULATION: First, second, and third live singleton births to women aged 20 years or older in Sweden, from 1990 to 2011 (n = 2 009 068).

METHODS: Logistic regression analysis was used in each parity group to estimate risks of very and moderately preterm births to women at 20-24, 25-29, 30-34, 35-39, and 40 years or older, using 25-29 years as the reference group. Odds ratios (ORs) were adjusted for year of birth, education, country of birth, smoking, body mass index, and history of preterm birth. Age-related risks of spontaneous and medically indicated preterm births were also investigated.

MAIN OUTCOME MEASURES: Very preterm (22-31 weeks of gestation) and moderately preterm (32-36 weeks) births.

RESULTS: Risks of very preterm birth increased with maternal age, irrespective of parity: adjusted ORs in first, second, and third births ranged from 1.18 to 1.28 at 30-34 years, from 1.59 to 1.70 at 35-39 years, and from 1.97 to 2.40 at ≥40 years. In moderately preterm births, age-related associations were weaker, but were statistically significant from 35-39 years in all parity groups. Advanced maternal age increased the risks of both spontaneous and medically indicated preterm births.

CONCLUSIONS: Advanced maternal age is associated with an increased risk of preterm birth, irrespective of parity, especially very preterm birth. Women aged 35 years and older, expecting their first, second, or third births, should be regarded as a risk group for very preterm birth.

Place, publisher, year, edition, pages
2017. Vol. 124, no 8, 1235-1244 p.
Keyword [en]
Maternal age; parity; preterm birth
National Category
Clinical Medicine
Research subject
Health and Welfare
Identifiers
URN: urn:nbn:se:du-23280DOI: 10.1111/1471-0528.14368ISI: 000403938600025PubMedID: 27770495Scopus ID: 2-s2.0-85020931829OAI: oai:DiVA.org:du-23280DiVA: diva2:1039820
Available from: 2016-10-25 Created: 2016-10-25 Last updated: 2017-07-31Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
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More styles
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