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Endostatin: a promising biomarker in the cardiovascular continuum?
Dalarna University, School of Education, Health and Social Studies, Medical Science. Karolinska institutet.ORCID iD: 0000-0002-6933-4637
2017 (English)In: Biomarkers in Medicine, ISSN 1752-0363, E-ISSN 1752-0371Article in journal (Refereed) Epub ahead of print
Abstract [en]

The current review article aims to provide an up-to-date summary of previous studies in humans that have reported the association between circulating endostatin levels and different cardiovascular phenotypes. We also aim to provide suggestions for future directions of future research evaluating endostatin as a clinically relevant cardiovascular biomarker. With a few exceptions, higher circulating levels of endostatin seem to reflect vascular and myocardial damage, and a worsened prognosis for cardiovascular events or mortality in individuals with hypertension, diabetes, kidney disease, cardiovascular disease, as well as in the general population. Circulating endostatin seems to be a promising biomarker for cardiovascular pathology, but there is not enough evidence to date to support the use of endostatin measurements in clinical practice.

Place, publisher, year, edition, pages
2017.
Keyword [en]
angiogenesis, atherosclerosis, biomarker, chronic kidney disease, collagen XVIII, epidemiological studies, extracellular matrix, glomerular filtration rate, heart failure, mortality
National Category
Clinical Medicine
Research subject
Health and Welfare
Identifiers
URN: urn:nbn:se:du-26384DOI: 10.2217/bmm-2017-0025PubMedID: 28976780OAI: oai:DiVA.org:du-26384DiVA: diva2:1147973
Available from: 2017-10-09 Created: 2017-10-09 Last updated: 2017-10-11Bibliographically approved

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CiteExportLink to record
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