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Systemic inflammatory markers in relation to lung function in NHANES. 2007–2010
Dalarna University, School of Education, Health and Social Studies, Medical Science. Uppsala University.ORCID iD: 0000-0003-3880-2132
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2018 (English)In: Respiratory Medicine, ISSN 0954-6111, E-ISSN 1532-3064, Vol. 142, p. 94-100Article in journal (Refereed) Published
Abstract [en]

Background Low-grade systemic inflammation, mainly assessed by C-reactive protein (CRP), has been associated with impaired lung function. Few studies have studied if CRP, blood eosinophils, and blood neutrophils offer additive information in relation to lung function. Objectives To analyse associations between lung function and CRP, blood eosinophils, and blood neutrophils, with special regard to additive information of combining the inflammatory markers. Methods Cross-sectional study on 7753 participants, 20–80 years of age, in the National Health and Nutrition Examination Survey. Gender-based tertiles for CRP, blood eosinophils, and blood neutrophils were analysed in relation to the following lung function parameters: forced expiratory volume in 1 s (FEV1% predicted), forced vital capacity (FVC % predicted), and FEV1/FVC ratio. Results CRP, blood eosinophils, and blood neutrophils levels were inversely related to FEV1 and FVC. Only blood eosinophils and blood neutrophils were inversely related to FEV1/FVC ratio. Further, lower lung function was found with increased number of elevated inflammatory markers in the highest tertile (one, two or three vs. non elevated) for FEV1 (β-coeff., −2.20, −4.43, and −6.43, p < 0.001) and FVC (β-coeff., −1.70, −3.15 and −5.33, p < 0.001), respectively. Conclusions & clinical relevance CRP, blood eosinophils, and blood neutrophils offer independent and additive information in relation to lower FEV1 and FVC in the general population. This indicates that a combination of biomarkers yields more information than the biomarkers assessed individually.

Place, publisher, year, edition, pages
2018. Vol. 142, p. 94-100
Keywords [en]
Inflammation, CRP, Blood eosinophils, Blood neutrophils
National Category
Clinical Medicine
Research subject
Health and Welfare
Identifiers
URN: urn:nbn:se:du-28458DOI: 10.1016/j.rmed.2018.07.011ISI: 000443001500015PubMedID: 30170809Scopus ID: 2-s2.0-85051648358OAI: oai:DiVA.org:du-28458DiVA, id: diva2:1244659
Available from: 2018-09-03 Created: 2018-09-03 Last updated: 2018-09-13Bibliographically approved

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CiteExportLink to record
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