Ketoconazole increases atovaquone exposure following concomitant administration with Malarone® in healthy subjectsShow others and affiliations
2022 (English)In: Journal of Travel Medicine, ISSN 1195-1982, E-ISSN 1708-8305, Vol. 29, no 4, article id taac058Article in journal (Refereed) Published
Abstract [en]
With an aim to assess the pharmacokinetics of atovaquone, 10 healthy subjects were administered Malarone® alone and in combination with ketoconazole in a crossover study. The results indicated 68% higher Cmax, 74% higher AUC and 34% lower CL/F of atovaquone following co-administration with ketoconazole compared to administration of atovaquone alone.
Place, publisher, year, edition, pages
2022. Vol. 29, no 4, article id taac058
Keywords [en]
Malarone, atovaquone, drug–drug interactions, ketoconazole, malaria chemoprophylaxis, pharmacokinetics, proguanil
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:du-41447DOI: 10.1093/jtm/taac058ISI: 000809392800001PubMedID: 35532299Scopus ID: 2-s2.0-85134429711OAI: oai:DiVA.org:du-41447DiVA, id: diva2:1658676
2022-05-172022-05-172024-07-04Bibliographically approved