Background and Aims: As there are few evaluated family interventions in pediatric oncology, this study aimed to pilot-test a family-based psychosocial intervention, the Family Talk Intervention (FTI), in pediatric oncology in terms of retention, delivery, response rate, and acceptability from the parents’ and ill children’s perspectives. Methods:This pre-post pilot study included 26 families (115 family members) affected by childhood cancer of which a majority had a CNS tumor or relapse. FTI is led by professionals, often social workers, and aims to facilitate family communication about illness-related subjects, e.g. prognosis, support parenting, and make the children’s needs visible. FTI encompasses six meetings, both individual and as a family. Meeting 5, referred to as “the family talk”, is preferably led by the parents. Extra meetings are offered if needed. This abstract includes observational and surveys data, and interviews with parents and ill children (sibling data is presented elsewhere). Results: All families who started FTI underwent the full intervention. Survey response rate varied between 100% and 71% over time. Extra meetings were held with most families. The parents stated that FTI filled a gap of support to the family as a unit and that, since FTI was conducted at home, it felt safe and supportive. According to most parents and ill children, FTI came right in time, included a reasonable number of meetings, with appropriate length. The family members felt listened to and understood. They reported that FTI had helped them, e.g. with family communication, adjustment of their behavior, and strengthened relationships. The parents valued the children’s perspectives being considered, but some felt uncomfortable leading meeting. Conclusions: FTI was valuable and helpful according to the parents and the ill children. Even if FTI seemed feasible in pediatric oncology it would benefit from being slightly modified before a large trial can be conducted.