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The association between sodium intake and coronary and carotid atherosclerosis in the general Swedish population
Karolinska Institutet, Huddinge; Center for Clinical Research Dalarna, Falun, Uppsala University.
Karolinska Institutet, Huddinge; Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Lund University, Malmö.
Lund University, Malmö.
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2023 (English)In: European Heart Journal Open, E-ISSN 2752-4191, Vol. 3, no 2, article id oead024Article in journal (Refereed) Published
Abstract [en]

AIMS: A high intake of salt raises blood pressure and the risk of cardiovascular disease. Previous studies have reported on the association between salt intake and carotid stenosis, but the association with coronary atherosclerosis has not been reported. Therefore, this project aimed at studying the association between salt intake and both carotid and coronary atherosclerosis in a contemporary community-based cohort.

METHODS AND RESULTS: Estimated 24-h sodium excretion (est24hNa) was calculated by the Kawasaki formula for participants of two sites (Uppsala and Malmö) of the Swedish Cardiopulmonary bioImage Study, who underwent a coronary computed tomography (n = 9623) and measurement of coronary artery calcium score (CACS, n = 10 289). Carotid ultrasound was used to detect carotid plaques (n = 10 700). Ordered logistic regression was used to calculate odds ratios (OR) per 1000 mg increase in est24hNa. We also investigated potential J-formed associations using quintiles of est24hNa. Increased est24hNa was associated with increased occurrence of carotid plaques [OR: 1.09, P < 0.001, confidence interval (CI): 1.06-1.12], higher CACS (OR: 1.16, P < 0.001, CI: 1.12-1.19), and coronary artery stenosis (OR: 1.17, P < 0.001, CI: 1.13-1.20) in minimal adjusted models. Associations were abolished when adjusting for blood pressure. When adjusting for established cardiovascular risk factors (not including blood pressure), associations remained for carotid plaques but not for coronary atherosclerosis. There was no evidence of J-formed associations.

CONCLUSION: Higher est24hNa was associated with both coronary and carotid atherosclerosis in minimal adjusted models. The association seemed mainly mediated by blood pressure but to some degree also influenced by other established cardiovascular risk factors.

Place, publisher, year, edition, pages
2023. Vol. 3, no 2, article id oead024
Keywords [en]
Atherosclerosis, Cardiovascular disease, Hypertension, Salt, Sodium
National Category
Cardiology and Cardiovascular Disease
Identifiers
URN: urn:nbn:se:du-45837DOI: 10.1093/ehjopen/oead024PubMedID: 37006408Scopus ID: 2-s2.0-85159714649OAI: oai:DiVA.org:du-45837DiVA, id: diva2:1749835
Available from: 2023-04-11 Created: 2023-04-11 Last updated: 2025-02-10Bibliographically approved

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Ärnlöv, Johan

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CiteExportLink to record
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Citation style
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  • ieee
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