Air pollution and meteorological conditions impact COVID-19 mortality rates. This research studied Quito, Ecuador, using Granger causality tests and regression models to investigate the relationship between pollutants, meteorological variables, human mobility, and excess deaths. Results suggested that Mobility as defined by Google Mobility Index, Facebook Isolation Index, in addition to Nitrogen Dioxide, and Sulphur Dioxide significantly impact excess deaths, while Carbon Monoxide and Relative Humidity have mixed results. Measures to reduce Carbon Monoxide emissions and increase humidity levels may mitigate the impact of air pollution on COVID-19 mortality rates. Further research is needed to investigate the impact of pollutants on COVID-19 transmission in other locations. Healthcare decision-makers must monitor and mitigate the impact of pollutants, promote healthy air quality policies, and encourage physical activity in safe environments. They must also consider meteorological conditions and implement measures such as increased ventilation and air conditioning to reduce exposure. Additionally, they must consider human mobility and reduce it to slow the spread of the diseases. Decisionmakers must monitor and track excess deaths during the pandemic to understand the impact of pollutants, meteorological conditions, and human mobility on human health. Public education is critical to raising awareness of air quality and its impact on health. Encouraging individuals to reduce their exposure to pollutants and meteorological conditions can play a critical role in mitigating the impact of air pollution on respiratory health during the pandemic.