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Quality of Life and Kidney Function in Older Adults: Prospective Data of the SCOPE Study
Ben-Gurion University of the Negev, Beer-Sheva, Israel; Maccabi Health Services, Southern District, Omer, Israel.
Friedrich-Alexander-Universität Erlangen-Nürnberg, Nürnberg, Germany.
Italian National Research Center on Aging (IRCCS INRCA), Ancona, Italy.
Italian National Research Center on Aging (IRCCS INRCA), Ancona, Italy.
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2023 (English)In: Journal of Clinical Medicine, E-ISSN 2077-0383, Vol. 12, no 12, article id 3959Article in journal (Refereed) Published
Abstract [en]

A longitudinal alteration in health-related quality of life (HRQoL) over a two-year period and its association with early-stage chronic kidney disease (CKD) progression was investigated among 1748 older adults (>75 years). HRQoL was measured by the Euro-Quality of Life Visual Analog Scale (EQ-VAS) at baseline and at one and two years after recruitment. A full comprehensive geriatric assessment was performed, including sociodemographic and clinical characteristics, the Geriatric Depression Scale-Short Form (GDS-SF), Short Physical Performance Battery (SPPB), and estimated glomerular filtration rate (eGFR). The association between EQ-VAS decline and covariates was investigated by multivariable analyses. A total of 41% of the participants showed EQ-VAS decline, and 16.3% showed kidney function decline over the two-year follow-up period. Participants with EQ-VAS decline showed an increase in GDS-SF scores and a greater decline in SPPB scores. The logistic regression analyses showed no contribution of a decrease in kidney function on EQ-VAS decline in the early stages of CKD. However, older adults with a greater GDS-SF score were more likely to present EQ-VAS decline over time, whereas an increase in the SPPB scores was associated with less EQ-VAS decline. This finding should be considered in clinical practice and when HRQoL is used to evaluate health interventions among older adults.

Place, publisher, year, edition, pages
2023. Vol. 12, no 12, article id 3959
Keywords [en]
chronic kidney disease, cohort studies, disease progression, older adults, prospective studies, quality of life
National Category
Geriatrics Gerontology, specialising in Medical and Health Sciences
Identifiers
URN: urn:nbn:se:du-46363DOI: 10.3390/jcm12123959ISI: 001017402300001PubMedID: 37373653Scopus ID: 2-s2.0-85163761660OAI: oai:DiVA.org:du-46363DiVA, id: diva2:1779317
Available from: 2023-07-04 Created: 2023-07-04 Last updated: 2023-08-04Bibliographically approved

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Ärnlöv, Johan

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CiteExportLink to record
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Citation style
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