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One-year follow up of contraceptive use and pregnancy rates after early medical abortion: Secondary outcomes from a randomized controlled trial of immediate post-abortion placement of intrauterine devices.
Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm; Center for Clinical Research Dalarna, Uppsala University, Falun.
Dalarna University, School of Health and Welfare, Sexual Reproductive Perinatal Health. Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm; Center for Clinical Research Dalarna, Uppsala University, Falun.ORCID iD: 0000-0003-2813-7642
Department of Women's and Children's Health, Karolinska Institutet, Stockholm; World Health Organization Collaborating Centre for Research and Research Training in Human Reproduction, Stockholm; Department of Gynecology and Reproductive medicine, Karolinska University Hospital, Stockholm.
Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm; Department of Obstetrics and Gynecology, Danderyd Hospital, Stockholm.
2023 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 102, no 12, p. 1694-1702Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: Intrauterine devices (IUDs) effectively prevent unwanted pregnancies. Little is known about long-term outcomes of women choosing an IUD after early medical abortion.

MATERIAL AND METHODS: We present secondary outcome data of continuation rates, factors associated with continuation and discontinuation, choice of IUD type, women's satisfaction with IUD, and IUD expulsions, subsequent pregnancies, and abortions within 1 year post-abortion in a randomized, controlled, multicenter trial on IUD placement within 48 hours compared with placement 2-4 weeks after medical abortion up to 63 days' gestation (ClinicalTrials.gov NCT03603145).

RESULTS: Of the 240 women studied, 112/120 (93.3%) in the intervention group vs 113/120 (94.2%) in the control group completed the 12-month follow-up. The rate of IUD use at 12 months was 84/112 (75%) in the intervention group vs 75/113 (66.4%) in the control group (P = 0.19). Attendance at the IUD placement visit was the only predictor of long-term IUD use (relative risk [RR] = 5.7, 95% confidence interval [CI] 2.03-16.0; P = 0.001). The main reason for choosing an IUD was high contraceptive effectiveness. The most common reasons for IUD discontinuation were bleeding problems and abdominal pain. IUD expulsion was rare and did not differ between groups. Satisfaction among IUD users at 1 year was high (>94%) and the majority of all participants would recommend IUD to a friend (65.8%). Use of no contraception and experience of unprotected intercourse were less common in the intervention group (11/112 [9.8%] vs 25/113 [22.1%], P = 0.02 and 17/112 [15.2%] vs 32/113 [28.3%], P = 0.02, respectively). There was no difference in the rate of subsequent pregnancies and abortions (pregnancies 14/112, 12.5% in the intervention group vs 8/113, 7.1% in the control group, P = 0.19; abortions 5/112, 4.5% vs 3/113, 2.7%, P = 0.5).

CONCLUSIONS: IUD placement after medical abortion led to high continuation and satisfaction rates with no difference between groups. We found no difference in IUD expulsions after immediate compared with later placement. Unprotected intercourse was significantly less common in the immediate group. In clinical practice, immediate placement of IUDs available free of charge at the abortion clinic is likely to increase attendance to the placement visit and continued use of IUDs after abortion.

Place, publisher, year, edition, pages
2023. Vol. 102, no 12, p. 1694-1702
Keywords [en]
abortion, contraception, contraceptive devices, copper intrauterine devices, family planning services, intrauterine devices, long-acting reversible contraceptives, medicated intrauterine devices
National Category
Gynaecology, Obstetrics and Reproductive Medicine
Identifiers
URN: urn:nbn:se:du-46878DOI: 10.1111/aogs.14662ISI: 001053534300001PubMedID: 37614066Scopus ID: 2-s2.0-85168627912OAI: oai:DiVA.org:du-46878DiVA, id: diva2:1793651
Available from: 2023-09-01 Created: 2023-09-01 Last updated: 2025-02-11Bibliographically approved

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Envall, Niklas

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