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Reducing Epistasis and Pleiotropy Can Avoid the Survival of the Flattest Tragedy
Dalarna University, School of Information and Engineering, Microdata Analysis.ORCID iD: 0000-0001-9523-6689
Dalarna University, School of Information and Engineering, Microdata Analysis. BEACON Center for the Study of Evolution in Action, Michigan State University, East Lansing, USA.ORCID iD: 0000-0002-4872-1961
2024 (English)In: Biology, E-ISSN 2079-7737, Vol. 13, no 3, article id 193Article in journal (Refereed) Published
Abstract [en]

This study investigates whether reducing epistasis and pleiotropy enhances mutational robustness in evolutionary adaptation, utilizing an indirect encoded model within the “survival of the flattest” (SoF) fitness landscape. By simulating genetic variations and their phenotypic consequences, we explore organisms’ adaptive mechanisms to maintain positions on higher, narrower evolutionary peaks amidst environmental and genetic pressures. Our results reveal that organisms can indeed sustain their advantageous positions by minimizing the complexity of genetic interactions—specifically, by reducing the levels of epistasis and pleiotropy. This finding suggests a counterintuitive strategy for evolutionary stability: simpler genetic architectures, characterized by fewer gene interactions and multifunctional genes, confer a survival advantage by enhancing mutational robustness. This study contributes to our understanding of the genetic underpinnings of adaptability and robustness, challenging traditional views that equate complexity with fitness in dynamic environments. © 2024 by the authors.

Place, publisher, year, edition, pages
MDPI, 2024. Vol. 13, no 3, article id 193
Keywords [en]
epistasis, mutational robustness, pleiotropy, survival of the flattest
National Category
Evolutionary Biology
Identifiers
URN: urn:nbn:se:du-48311DOI: 10.3390/biology13030193ISI: 001191567600001PubMedID: 38534462Scopus ID: 2-s2.0-85188680430OAI: oai:DiVA.org:du-48311DiVA, id: diva2:1848179
Available from: 2024-04-02 Created: 2024-04-02 Last updated: 2024-04-09

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Mehra, PriyankaHintze, Arend

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Citation style
  • apa
  • ieee
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More styles
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  • de-DE
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