Vibration transfer analysis, a well-established method for characterizing the dynamics of mechanical systems, was integrated with a multi-degree-of-freedom (DOF) platform incorporating inertial measurement technology, to measure the dynamic behavior of complex response. A 6-DOF dynamic model was developed for a platform featuring an oblique-mounted pyramid configuration and rigidly-hinged-mixed support to address platform-based vibration analysis requirements. Vehicle excitation served as the vibration source to measure the dynamic response of the platform, which was converted into a transfer function to quantify vibration transfer while reducing noise interference. A transfer function-oriented model updating method improved accuracy, and the parametric study using the updated model guided the vibration isolation optimization. Results demonstrate that the proposed platform configuration achieves effective 6-DOF vibration isolation performance in the low-frequency range.