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A new approach to evaluate stability of amodiaquine and its metabolite in blood and plasma
Dalarna University, School of Technology and Business Studies, Chemical Engineering.
Dalarna University, School of Technology and Business Studies, Chemical Engineering.
2006 (English)In: Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, E-ISSN 1873-264X, Vol. 41, no 1, p. 207-212Article in journal (Refereed) Published
Abstract [en]

A stability study for amodiaquine (AQ) and desethylamodiaquine (AQm) in whole blood and plasma is reported. AQ, AQm and chloroquine (CQ) were simultaneously analysed and the ratios AQ/CQ and AQm/CQ were used to ensure correct interpretation of the stability results. CQ was stable in whole blood and plasma at all tested temperatures enabling it to be a stability marker in stability studies. Simultaneous analysis of compounds, of which at least one is already known to be stable, permits a within sample ratio to be used as a stability indicator, The new approach significantly reduced bias when compared to the traditional approach. AQ and AQm were stable in plasma at -86 degrees C and -20 degrees C for 35 days, at 4 degrees C for 14 days and at 22 degrees C for 1 day. AQ and AQm were stable in blood at -86 degrees C and 4 degrees C for 35 days, at -20 degrees C and 22 degrees C for 7 days and at 37 degrees C for 1 day.

Place, publisher, year, edition, pages
2006. Vol. 41, no 1, p. 207-212
Keywords [en]
antimalarial; amoditiquine; chloroquine; desethylamodiaquine; liquid chromatography; solid-phase extraction; stability
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:du-1619DOI: 10.1016/j.jpba.2005.10.018ISI: 000236655100028PubMedID: 16307860OAI: oai:dalea.du.se:1619DiVA, id: diva2:519574
Available from: 2005-12-21 Created: 2005-12-21 Last updated: 2017-12-07Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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