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Oral cryotherapy reduces mucositis and opioid use after myeloablative therapy: a randomized control trial
Dalarna University, School of Education, Health and Social Studies, Caring Science/Nursing.ORCID iD: 0000-0003-2960-4994
Dalarna University, School of Education, Health and Social Studies, Health and Caring Sciences/Oral Health Science.ORCID iD: 0000-0002-7972-1470
2007 (English)In: Supportive Care in Cancer, ISSN 0941-4355, E-ISSN 1433-7339, Vol. 15, no 10, p. 1155-1161Article in journal (Refereed) Published
Abstract [en]

Introduction. Mucositis is a major complication in myeloablative therapy, which often necessitates advanced pharmacological pain treatment, including i.v. opioids. Attempts to prevent oral mucositis have included oral cryotherapy, which has been shown to reduce mucositis, but there is a lack of knowledge concerning the effect of oral cryotherapy on opioid use by reducing the mucositis for patients treated with myeloablative therapy before bone marrow transplantation (BMT). 

Aim. The aim of the present study was to evaluate if oral cryotherapy could delay or alleviate the development of mucositis and thereby reduce the number of days with i.v. opioids among patients who receive myeloablative therapy before BMT. 

Materials and methods. Eighty patients 18 years and older, scheduled for BMT, were included consecutively and randomised to oral cryotherapy or standard oral care. A stratified randomisation was used with regard to type of transplantation. Intensity of pain, severity of mucositis and use of opioids were recorded using pain visual analogue scale (VAS) scores, mucositis index scores and medical and nursing charts. 

Results. This study showed that patients receiving oral cryotherapy had less pronounced mucositis and significantly fewer days with i.v. opioids than the control group. In the autologous setting, cryotherapy patients also needed significantly lower total dose of opioids. 

Conclusion. Oral cryotherapy is an effective and well-tolerated therapy to alleviate mucositis and consequently reduce the number of days with i.v. opioids among patients treated with myeloablative therapy before BMT.

Place, publisher, year, edition, pages
2007. Vol. 15, no 10, p. 1155-1161
Keywords [en]
oral cryotherapy, bone marrow transplantation, mucositis, oral pain, opioid use
National Category
Health Sciences
Research subject
Hälsa och välfärd, Oral cryoterapi för patienter som behandlas med cytostatika
Identifiers
URN: urn:nbn:se:du-2581DOI: 10.1007/s00520-007-0245-8ISI: 000249632900004PubMedID: 17393189OAI: oai:dalea.du.se:2581DiVA, id: diva2:519769
Available from: 2007-03-28 Created: 2007-03-28 Last updated: 2017-12-07Bibliographically approved

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Svanberg, AnncarinÖhrn, Kerstin

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