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Straightforward and rapid determination of sulfadoxine and sulfamethoxazole in capillary blood on sampling paper with liquid chromatography and UV detection
Dalarna University, School of Technology and Business Studies, Chemical Engineering.
Dalarna University, School of Technology and Business Studies, Chemical Engineering.
Dalarna University, School of Education, Health and Social Studies, Medical Science.
2009 (English)In: Transactions of the Royal Society of Tropical Medicine and Hygiene, ISSN 0035-9203, E-ISSN 1878-3503, Vol. 103, no 4, p. 371-376Article in journal (Refereed) Published
Abstract [en]

A method for the determination of sulfadoxine and sulfamethoxazole in capillary blood on sampling paper has been developed and validated. The method is straightforward with minimal sample preparation, and is suitable for rural settings. Separation of sulfadoxine, sulfamethoxazole and internal standard was performed using a Purospher STAR RP-18 endcapped LC column (150 x 4.6 mm) with a mobile phase consisting of acetonitrile: sodium acetate buffer pH 5.2, 1=0.1 (1:2, v/v). For sulfadoxine, the within-day precision was 5.3% at 15 mu mol/l and 3.7% at 600 mu mol/l, while for sulfamethoxazole it was 5.7% at 15 mu mol/l and 3.8% at 600 mu mol/l. The tower limit of quantification was determined to 5 mu mol/l and precision was 5.5% and 5.0% for sulfadoxine and sulfamethoxazole, respectively.

Place, publisher, year, edition, pages
2009. Vol. 103, no 4, p. 371-376
Keywords [en]
Malaria; Pneumonia; Sulfadoxine; Sulfamethoxazole; Chromatography; Dried blood spots
National Category
Chemical Engineering
Identifiers
URN: urn:nbn:se:du-2659DOI: 10.1016/j.trstmh.2008.11.031ISI: 000264976700009PubMedID: 19185326OAI: oai:dalea.du.se:2659DiVA, id: diva2:519794
Available from: 2007-04-04 Created: 2007-04-04 Last updated: 2017-12-07Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
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Language
  • de-DE
  • en-GB
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  • nn-NO
  • nn-NB
  • sv-SE
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Output format
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