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Skeletal muscle morphology in patients with Restless legs syndrome (RLS)
Dalarna University, School of Education, Health and Social Studies, Medical Science.
2007 (English)In: European Journal of Neurology, ISSN 1351-5101, E-ISSN 1468-1331, Vol. 58, no 3, p. 133-137Article in journal (Refereed) Published
Abstract [en]

Aim: The aim of the study was to assess the cellular and structural properties of skeletal muscle in Restless legs Syndrome (RLS).

Method: Twenty patients and 16 controls were included. Aerobic performance was assessed using a sub maximal test. On muscle biopsies taken from the tiabialis anterior, fibre distribution and fibre area were analysed together with parameters surveying the microvascularisation, especially the tortuosity which is expressed as a percent of muscle fibre perimeter in contact with the wall of the microvessel, LC/PF-index (length of capillary / perimeter of fibre).

Result: RLS group had significantly lower predicted maximal oxygen uptake (p = 0.01) and significantly higher LC/PF index (P=0.01) compared to the controls. In conclusion, the higher capillary tortuosity in RLS patients indicates the occurrence of significant remodelling in capillary geometry in RLS.

Place, publisher, year, edition, pages
2007. Vol. 58, no 3, p. 133-137
Keywords [en]
restless legs syndrome, capillary, skeletal muscle, hypoxia
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:du-2841DOI: 10.1159/000104712ISI: 000249536800002PubMedID: 17622717OAI: oai:dalea.du.se:2841DiVA, id: diva2:519852
Available from: 2007-06-15 Created: 2007-06-15 Last updated: 2017-12-07Bibliographically approved

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