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Non-iterative variance component estimation in QTL analysis.
Dalarna University, School of Technology and Business Studies, Statistics.ORCID iD: 0000-0002-1057-5401
2009 (English)In: Journal of Animal Breeding and Genetics, ISSN 0931-2668, E-ISSN 1439-0388, Vol. 126, no 1, p. 110-116Article in journal (Refereed) Published
Abstract [en]

In variance component quantitative trait loci (QTL) analysis, a mixed model is used to detect the most likely chromosome position of a QTL. The putative QTL is included as a random effect and a method is needed to estimate the QTL variance. The standard estimation method used is an iterative method based on the restricted maximum likelihood (REML). In this paper, we present a novel non-iterative variance component estimation method. This method is based on Henderson's method 3, but relaxes the condition of unbiasedness. Two similar estimators were compared, which were developed from two different partitions of the sum of squares in Henderson's method 3. The approach was compared with REML on data from a European wild boar × domestic pig intercross. A meat quality trait was studied on chromosome 6 where a functional gene was known to be located. Both partitions resulted in estimated QTL variances close to the REML estimates. From the non-iterative estimates, we could also compute good approximations of the likelihood ratio curve on the studied chromosome.

Place, publisher, year, edition, pages
Wiley-Blackwell , 2009. Vol. 126, no 1, p. 110-116
National Category
Probability Theory and Statistics
Research subject
Research Profiles 2009-2020, Complex Systems – Microdata Analysis
Identifiers
URN: urn:nbn:se:du-3666DOI: 10.1111/j.1439-0388.2008.00780.xISI: 000264241300004OAI: oai:dalea.du.se:3666DiVA, id: diva2:519997
Available from: 2009-01-30 Created: 2009-01-30 Last updated: 2021-11-12Bibliographically approved

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Rönnegård, Lars

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CiteExportLink to record
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Citation style
  • apa
  • ieee
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  • vancouver
  • chicago-author-date
  • chicago-note-bibliography
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf