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Detecting major genetic loci controlling phenotypic variability in experimental crosses
Dalarna University, School of Technology and Business Studies, Statistics.ORCID iD: 0000-0002-1057-5401
2011 (English)In: Genetics, ISSN 0016-6731, E-ISSN 1943-2631, Vol. 188, no 2, 435-447 p.Article in journal (Refereed) Published
Abstract [en]

Traditional methods for detecting genes that affect complex diseases in humans or animal models, milk production in livestock, or other traits of interest, have asked whether variation in genotype produces a change in that trait’s average value. But focusing on differences in the mean ignores differences in variability about that mean. The robustness, or uniformity, of an individual’s character is not only of great practical importance in medical genetics and food production but is also of scienti?c and evolutionary interest (e.g., blood pressure in animal models of heart disease, litter size in pigs, ?owering time in plants). We describe a method for detecting major genes controlling the phenotypic variance, referring to these as vQTL. Our method uses a double generalized linear model with linear predictors based on probabilities of line origin. We evaluate our method on simulated F2 and collaborative cross data, and on a real F2 intercross, demonstrating its accuracy and robustness to the presence of ordinary mean-controlling QTL. We also illustrate the connection between vQTL and QTL involved in epistasis, explaining how these concepts overlap. Our method can be applied to a wide range of commonly used experimental crosses and may be extended to genetic association more generally.

Place, publisher, year, edition, pages
London: Biomed Central , 2011. Vol. 188, no 2, 435-447 p.
National Category
Probability Theory and Statistics
Research subject
Complex Systems – Microdata Analysis, Statistisk modellering är grunden till en ökad förståelse inom genetik!
Identifiers
URN: urn:nbn:se:du-5565DOI: 10.1534/genetics.111.127068ISI: 000291344900016OAI: oai:dalea.du.se:5565DiVA: diva2:520367
Available from: 2011-06-14 Created: 2011-06-14 Last updated: 2017-04-04Bibliographically approved

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CiteExportLink to record
Permanent link

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Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • chicago-author-date
  • chicago-note-bibliography
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
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  • asciidoc
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