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Analysis of response to enteral infusion of levodopa in patients with Parkinson's disease
Dalarna University, School of Technology and Business Studies, Computer Engineering.ORCID iD: 0000-0003-0403-338X
Dalarna University, School of Technology and Business Studies, Computer Engineering.
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2004 (English)In: Movement Disorders 2004; 19(S9):165-166, Rome, 2004, Vol. PosterConference paper, (Refereed)
Abstract [en]

Objective: We present a new evaluation of levodopa plasma concentrations and clinical effects during duodenal infusion of a levodopa/carbidopa gel (Duodopa ) in 12 patients with advanced Parkinson s disease (PD), from a study reported previously (Nyholm et al, Clin Neuropharmacol 2003; 26(3): 156-163). One objective was to investigate in what state of PD we can see the greatest benefits with infusion compared with corresponding oral treatment (Sinemet CR). Another objective was to identify fluctuating response to levodopa and correlate to variables related to disease progression. Methods: We have computed mean absolute error (MAE) and mean squared error (MSE) for the clinical rating from -3 (severe parkinsonism) to +3 (severe dyskinesia) as measures of the clinical state over the treatment periods of the study. Standard deviation (SD) of the rating was used as a measure of response fluctuations. Linear regression and visual inspection of graphs were used to estimate relationships between these measures and variables related to disease progression such as years on levodopa (YLD) or unified PD rating scale part II (UPDRS II). Results: We found that MAE for infusion had a strong linear correlation to YLD (r2=0.80) while the corresponding relation for oral treatment looked more sigmoid, particularly for the more advanced patients (YLD>18).

Place, publisher, year, edition, pages
Rome, 2004. Vol. Poster
Keyword [en]
Parkinson, fluctuation, improvement measure, response, levodopa infusion
Identifiers
URN: urn:nbn:se:du-1907OAI: oai:dalea.du.se:1907DiVA: diva2:521573
Conference
The Movement Disorder Society's 8th International Congress on Parkinson's disease and Movement Disorders , Rome, 2004
Available from: 2006-03-07 Created: 2006-03-07 Last updated: 2015-06-01Bibliographically approved

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CiteExportLink to record
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Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
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