Relationships between, on the one hand, computer experience, neuroticism , extra-introversion , and, on the other, experienced “stress” in situations involving computer problems were investigated. Ninety subjects, 50 female and 40 male students from Dalarna college university, took part. Eysenck´s Personality Inventory was used to assess neuroticism (N) and extra-introversion (E) . Eight scenarios, describing assumedly stressful situations, were constructed. Four of them involved computer problems. The subjects were asked to rate the degree of stress, they would experience in the situations described. Principal component analysis, using the 8 scenarios and the “stress” ratings of the 90 subjects as input, indicated that individuals who react strongly when running into computer problems also tend to react strongly when running into other problems. Women experienced significantly more “stress” than men in all 8 situations described. Women obtained significantly higher N scores than men, but there were no sex difference as to the E scores. Women also had less computer experience. Multiple regression analysis with sex, computer experience, N- and E scores as independent variables and experienced “stress” in situations involving computer problems as dependent, gave significant effects of gender and computer experience, but not of N and E scores. A two-way ANOVA gave a significant interaction between gender and N as to their effects on experienced “computer stress”. There was a significant correlation (P<.01) for men, but not for women, between N and “computer stress”. It is suggested that, besides experience with computers, a higher level of computer anxiety among women than men could be linked to the personality factor N. However, it is far from clear to what extent sex differences in the N factor should be attributed to biological factors, and to what extent cultural factors contribute.