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Sodium bicarbonate ingestion prior to training improves mitochondrial adaptations in rats
Dalarna University, School of Education, Health and Social Studies, Sport and Health Science.
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2010 (English)In: American Journal of Physiology. Endocrinology and Metabolism, ISSN 0193-1849, E-ISSN 1522-1555, Vol. 299, no 2, E225-E233 p.Article in journal (Refereed) Published
Abstract [en]

We tested the hypothesis that reducing hydrogen ion accumulation during training would result in greater improvements in muscle oxidative capacity and time to exhaustion (TTE). Male Wistar rats were randomly assigned to one of three groups (CON, PLA, and BIC). CON served as a sedentary control, whereas PLA ingested water and BIC ingested sodium bicarbonate 30 min prior to every training session. Training consisted of seven to twelve 2-min intervals performed five times/wk for 5 wk. Following training, TTE was significantly greater in BIC (81.2 +/- 24.7 min) compared with PLA (53.5 +/- 30.4 min), and TTE for both groups was greater than CON (6.5 +/- 2.5 min). Fiber respiration was determined in the soleus (SOL) and extensor digitorum longus (EDL), with either pyruvate (Pyr) or palmitoyl carnitine (PC) as substrates. Compared with CON (14.3 +/- 2.6 nmol O(2).min(-1).mg dry wt(-1)), there was a significantly greater SOL-Pyr state 3 respiration in both PLA (19.6 +/- 3.0 nmol O(2).min(-1).mg dry wt(-1)) and BIC (24.4 +/- 2.8 nmol O(2).min(-1).mg dry wt(-1)), with a significantly greater value in BIC. However, state 3 respiration was significantly lower in the EDL from both trained groups compared with CON. These differences remained significant in the SOL, but not the EDL, when respiration was corrected for citrate synthase activity (an indicator of mitochondrial mass). These novel findings suggest that reducing muscle hydrogen ion accumulation during running training is associated with greater improvements in both mitochondrial mass and mitochondrial respiration in the soleus.

Place, publisher, year, edition, pages
2010. Vol. 299, no 2, E225-E233 p.
Keyword [en]
mitochondrial respiration; state 3 respiration; muscle pH; citrate synthase; muscle buffer capacity
National Category
Sport and Fitness Sciences
Research subject
Hälsa och välfärd
Identifiers
URN: urn:nbn:se:du-10477DOI: 10.1152/ajpendo.00738.2009ISI: 000279654600010PubMedID: 20484007OAI: oai:DiVA.org:du-10477DiVA: diva2:542760
Available from: 2012-08-03 Created: 2012-08-03 Last updated: 2015-09-14Bibliographically approved

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CiteExportLink to record
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Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
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  • chicago-author-date
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More styles
Language
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