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Day-to-day variation of urinary NGAL and rational for creatinine correction
Dalarna University, School of Education, Health and Social Studies, Medical Science.ORCID iD: 0000-0002-6933-4637
2013 (English)In: Clinical Biochemistry, ISSN 0009-9120, E-ISSN 1873-2933, Vol. 46, no 1-2, 70-72 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: The number of clinical studies evaluating the new tubular biomarker urinary neutrophil gelatinase-associated lipocalin (U-NGAL) in urine are increasing. There is no consensus whether absolute U-NGAL concentrations or urinary NGAL/creatinine (U-NGAL/Cr) ratios should be used when chronic tubular dysfunction is studied. The aim was to study the biological variation of U-NGAL in healthy subjects and the rational for urinary creatinine (U-Cr) correction in two different study samples.

DESIGN AND METHODS: To study biological variation of U-NGAL and U-NGAL/Cr ratio and the association between U-NGAL and U-Cr in healthy subjects 13 young males and females (median age 29years) collected morning urine in 10 consecutive days. Additionally, a random subsample of 400 males from a population-based cohort (aged 78years) collecting 24-hour urine during 1day was studied.

RESULTS: The calculated biological variation for absolute U-NGAL was 27% and for U-NGAL/Cr ratio, 101%. Absolute U-NGAL increased linearly with U-Cr concentration (the theoretical basis for creatinine adjustment) in the older males (R=0.19, P<0.001) and with borderline significance in the young adults (R=0.16, P=0.08). The U-NGAL/Cr ratio was, however, negatively associated with creatinine in the older males (R=-0.14, P<0.01) and in the young adults (R=-0.16, P=0.07) indicating a slight "overadjustment."

CONCLUSIONS: The study provides some support for the use of U-NGAL/Cr ratio but the rather large biological variation and risk of possible overadjustment need to be considered. Both absolute U-NGAL and U-NGAL/Cr ratios should be reported for the estimation of chronic tubular dysfunction.

Place, publisher, year, edition, pages
Elsevier, 2013. Vol. 46, no 1-2, 70-72 p.
Keyword [en]
Biological variation; Neutrophil gelatinase-associated lipocalin; Tubular biomarker; Creatinine ratio
National Category
Clinical Laboratory Medicine
Research subject
Hälsa och välfärd
Identifiers
URN: urn:nbn:se:du-11502DOI: 10.1016/j.clinbiochem.2012.09.022ISI: 000313406800015PubMedID: 23041245OAI: oai:DiVA.org:du-11502DiVA: diva2:579276
Available from: 2012-12-19 Created: 2012-12-19 Last updated: 2015-06-29Bibliographically approved

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CiteExportLink to record
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Citation style
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