du.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • chicago-author-date
  • chicago-note-bibliography
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Prostaglandin F2α formation is associated with mortality in a Swedish community-based cohort of older males
Department of Medical Sciences/Clinical Chemistry, Uppsala University, Uppsala SE-751 85, Sweden.
Dalarna University, School of Education, Health and Social Studies, Medical Science. Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.ORCID iD: 0000-0002-6933-4637
Department of Medical Sciences/Clinical Chemistry, Uppsala University, Uppsala SE-751 85, Sweden.
Department of Public Health and Caring Sciences/Oxidative Stress and Inflammation, Uppsala University, Uppsala, Sweden, Centre of Excellence-Inflammation, Uppsala University Hospital, Uppsala, Sweden, Laboratory of Biochemistry, Molecular Biology, and Nutrition, University d'Auvergne, Clermont-Ferrand, France.
2015 (English)In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 36, no 4, 238-243 p.Article in journal (Refereed) Published
Abstract [en]

AIMS: An increasing number of clinical studies highlight the importance of the inflammatory mediator prostaglandin F2α (PGF2α). Prostaglandin F2α activity has been suggested to play pivotal roles in the development of cardiovascular diseases and cancer. However, whether systemic PGF2α concentrations may signal mortality is unknown. The aim was to evaluate in vivo PGF2α formation, by measuring urinary 15-keto-dihydro-PGF2α, and mortality risk in a community setting.

METHODS AND RESULTS: Urinary 15-keto-dihydro-PGF2α was measured in a Swedish population of 670 men (aged 77-78 years) and the participants were followed up for a median of 9.7 years (383 died, among them 156 of cardiovascular causes and 102 of cancer). In Cox regression models, urinary 15-keto-dihydro-PGF2α was significantly associated with cardiovascular mortality [multivariate hazard ratio (HR) for 1 SD increase of urinary 15-keto-dihydro-PGF2α: 1.18; 95% CI:1.04-1.34; P = 0.01) independent of established cardiovascular risk factors including C-reactive protein. Urinary 15-keto-dihydro-PGF2α was also independently associated with total mortality (multivariate HR for 1 SD increase of urinary 15-keto-dihydro-PGF2α: 1.11; 95% CI: 1.01-1.21; P = 0.03). The combination of 15-keto-dihydro-PGF2α concentrations above the median and high serum high-sensitive C-reactive protein (>3 mg/L) was independently associated with a two-fold increased risk of cancer and total mortality (P = 0.02 and P < 0.001, respectively).

CONCLUSION: This is the first study to show that the inflammatory mediator PGF2α was independently associated with mortality and specifically cardiovascular mortality 10 years later. The results are in line with the emerging evidence of the importance of the inflammatory mediator PGF2α in fatal cardiovascular disease.

Place, publisher, year, edition, pages
2015. Vol. 36, no 4, 238-243 p.
National Category
Clinical Medicine
Research subject
Hälsa och välfärd
Identifiers
URN: urn:nbn:se:du-13384DOI: 10.1093/eurheartj/eht212ISI: 000351587900016PubMedID: 23786857OAI: oai:DiVA.org:du-13384DiVA: diva2:668962
Available from: 2013-12-02 Created: 2013-11-29 Last updated: 2015-05-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Ärnlöv, Johan
By organisation
Medical Science
In the same journal
European Heart Journal
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 539 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • chicago-author-date
  • chicago-note-bibliography
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf