The theme of displacement and a view of exile that differs from traditional definitions of the concept and its associations with feelings of loss and nostalgia are a constant in Colum McCann's oeuvre. Images of flight and fleeing are recurrent in his work and underscore the centrality that mobility occupies in his fictional world, in which these flights are, not infrequently, a metaphorical act of escapism from material reality and physical conditioning. However, mobility in Let the Great World Spin is articulated as a characteristically twenty-first century phenomenon in its emphasis on how interconnectivity beyond differences, especially in the form of transnational exchanges, characterizes contemporary societies and shapes individual realities and identities. This essay contends that this transnational interconnectivity is not only foregrounded at the narrative level, thematically and in terms of narrative structure; McCann's tangentially framing of this novel within American post-9/11 fiction, while formally echoing an Irish literature of exile and thematically relating to an Irish literature of migration and fictions of the global, suggests the process in which new imaginative realities and identities are shaped from a cosmopolitan outlook that promotes the synergetic dialogue between national and transnational differences in the creation of a cosmopolitanized reality.