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Five-year follow-up of survival and relapse in patients who received cryotherapy during high-dose chemotherapy for stem cell transplantation shows no safety concerns
Uppsala Univ, Fac Med, Inst Med Sci, Uppsala, Sweden.ORCID iD: 0000-0003-2960-4994
Dalarna University, School of Education, Health and Social Studies, Health and Caring Sciences/Oral Health Science.ORCID iD: 0000-0002-7972-1470
Uppsala Univ, Fac Med, Inst Med Sci, Uppsala, Sweden.
2012 (English)In: European Journal of Cancer Care, ISSN 0961-5423, E-ISSN 1365-2354, Vol. 21, no 6, p. 822-828Article in journal (Refereed) Published
Abstract [en]

We have previously published a randomised controlled study of the efficacy of cryotherapy in preventing acute oral mucositis after high-dose chemotherapy for stem cell transplantation. The present study is a 5-year follow-up safety study of survival in these patients. In the previously published study oral cryotherapy (cooling of the oral cavity) during high-dose chemotherapy significantly reduced mucositis grade and opiate use in the treated group. All patients were followed up for at least 5 years with regard to relapse and death rates. Baseline data, transplant complications and mucositis data were compared. Significantly more patients (25/39) who received oral cryotherapy were alive after 5 years compared to 15/39 in the control group (P= 0.025). Relapse rates were similar. The only baseline difference was a lower proportion of patients in complete remission at transplantation in the control group (6 vs. 13, P= 0.047). This 5-year follow-up study gave no support for safety concerns with cryotherapy.

Place, publisher, year, edition, pages
2012. Vol. 21, no 6, p. 822-828
Keywords [en]
prevention; haematopoietic stem cell transplantation; chemotherapy; survival
National Category
Clinical Medicine
Research subject
Research Profiles 2009-2020, Health and Welfare
Identifiers
URN: urn:nbn:se:du-15520DOI: 10.1111/ecc.12009ISI: 000314038700016PubMedID: 22967016Scopus ID: 2-s2.0-84867910464OAI: oai:DiVA.org:du-15520DiVA, id: diva2:746303
Available from: 2014-09-12 Created: 2014-09-12 Last updated: 2021-11-12Bibliographically approved

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Svanberg, AnncarinÖhrn, Kerstin

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