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Infant body composition and adipokine concentrations in relation to maternal gestational weight gain
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2014 (English)In: Diabetes Care, ISSN 0149-5992, E-ISSN 1935-5548, Vol. 37, no 5, 1432-1438 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE. To investigate associations of maternal gestational weight gain and body composition and their impact on offspring body composition and adipocytokine, glucose, and insulin concentrations at age 4 months.

RESEARCH DESIGN AND METHODS. This was a prospective study including 31 mother-infant pairs (N = 62). Maternal body composition was assessed using doubly labeled water. Infant body composition was assessed at 4 months using air displacement plethysmography, and venous blood was assayed for glucose, insulin, adiponectin, interleukin-6 (IL-6), and leptin concentrations.

RESULTS. Rate of gestational weight gain in midpregnancy was significantly associated with infant fat mass (r = 0.41, P = 0.03); rate of gestational weight in late pregnancy was significantly associated with infant fat-free mass (r = 0.37, P = 0.04). Infant birth weight was also strongly correlated with infant fat-free mass at 4 months (r = 0.63, P = 0.0002). Maternal BMI and maternal fat mass were strongly inversely associated with infant IL-6 concentrations (r = -0.60, P = 0.002 and r = -0.52, P = 0.01, respectively). Infant fat-free mass was inversely related to infant adiponectin concentrations (r = -0.48, P = 0.008) and positively correlated with infant blood glucose adjusted for insulin concentrations (r = 0.42, P = 0.04). No significant associations for leptin were observed.

CONCLUSIONS. Timing of maternal weight gain differentially impacts body composition of the 4-month-old infant, which in turn appears to affect the infant's glucose and adipokine concentrations.

Place, publisher, year, edition, pages
2014. Vol. 37, no 5, 1432-1438 p.
National Category
Health Sciences
Research subject
Hälsa och välfärd
Identifiers
URN: urn:nbn:se:du-18576DOI: 10.2337/dc13-2265ISI: 000334840100060PubMedID: 24623025OAI: oai:DiVA.org:du-18576DiVA: diva2:833193
Available from: 2015-06-30 Created: 2015-06-29 Last updated: 2015-06-30Bibliographically approved

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Persson, MargaretaDomellof, Magnus
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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf