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Circulating alpha-tocopherol and insulin sensitivity among older men with chronic kidney disease
Dalarna University, School of Education, Health and Social Studies, Medical Science. Uppsala university.ORCID iD: 0000-0002-6933-4637
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2016 (English)In: Journal of renal nutrition (Print), ISSN 1051-2276, E-ISSN 1532-8503, Vol. 26, no 3, 177-182 p.Article in journal (Refereed) Published
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Abstract [en]

Objective: Insulin resistance is common in individuals with chronic kidney disease (CKD) and may be partly explained by modifiable risk factors. In the general population, vitamin E supplementation has been suggested to improve both insulin sensitivity and secretion. We here explore the potential role of vitamin E as a modifiable risk factor for insulin resistance among individuals with CKD.

Design: Observational study.

Setting: A total of 273 nondiabetic men aged 70 to 71 years with CKD defined as either cystatin C estimated glomerular filtration rate < 60 mL/minute/1.73 m2 or urinary albumin excretion rate ≥ 20 mg/minute from the third examination cycle of Uppsala Longitudinal Study of Adult Men.

Subjects: A total of 273 nondiabetic men aged 70 to 71 years with CKD defined as either cystatin C estimated glomerular filtration rate < 60 mL/minute/1.73 m2 or urinary albumin excretion rate ≥ 20 μg/minute.

Methods: Serum α-, β-, and γ-tocopherol concentrations were measured by high-performance liquid chromatography and expressed as μmol/total serum cholesterol and triglycerides (in mmol). Dietary vitamin E intake was estimated from 7-day food records.

Main Outcome Measure: Insulin sensitivity index (M/I ratio) was measured by hyperinsulinemic-euglycemic glucose clamps. Univariate and multivariate regression models were fitted to assess the association between M/I and circulating concentrations of tocopherols.

Results: The mean serum concentration of α-, β-, and γ- was 37.4 ± 6.58, 0.89 ± 0.23, and 4.32 ± 1.69 μmol/mmol, respectively. Median dietary vitamin E intake was 6.14 (interquartile range, 5.48-6.82) mg/day. In crude and fully-adjusted multivariate regression analyses, serum α-tocopherol levels were directly and strongly associated with M/I (standard β = 0.17, P = .003). No such association was observed for dietary vitamin E, serum β-, and γ-tocopherol concentrations.

Conclusions: Serum α-tocopherol concentration associates with insulin sensitivity in nondiabetic older men with CKD. 

Place, publisher, year, edition, pages
2016. Vol. 26, no 3, 177-182 p.
National Category
Clinical Medicine
Research subject
Health and Welfare
Identifiers
URN: urn:nbn:se:du-20789DOI: 10.1053/j.jrn.2015.11.005ISI: 000377983600009PubMedID: 26776598Scopus ID: 2-s2.0-84953333244OAI: oai:DiVA.org:du-20789DiVA: diva2:894622
Available from: 2016-01-15 Created: 2016-01-15 Last updated: 2016-12-20Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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