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Associations between cathepsin B and inflammation markers in elderly males and females
Dalarna University, School of Education, Health and Social Studies, Medical Science.ORCID iD: 0000-0002-6933-4637
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2015 (English)In: Horizons in World Cardiovascular Research, Nova Science Publishers, Inc., 2015, Vol. 8, 157-164 p.Chapter in book (Refereed)Text
Abstract [en]

Background: The association between cathepsin B and inflammatory disorders is being increasingly recognized, but the underlying mechanism is less understood. The aim of the present study was to study the association between cathepsin B and different inflammation markers in a community-based cohort of elderly males and females.

Methods: Blood samples were collected from 729 individuals in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort at the age of 75 years. Cathepsin B and the inflammation markers CRP, Pentraxin 3, TNF receptor 1 and TNF receptor 2 were analyzed together with albumin, cholesterol, HDL-cholesterol, LDL-cholesterol, cholesterol, apolipoprotein A1, apolipoprotein B and triglycerides.

Results: Cathepsin B was significantly associated with TNF receptor 1 and 2 (P<0.001) but not with CRP and pentraxin 3. There were also significant associations with cholesterol, LDL and apolipoprotein B.

Conclusion: The type of inflammatory response is of importance for circulating cathepsin B. The association between cathepsin B and the cardiovascular risk markers cholesterol, LDL-cholesterol and apolipoprotein B could contribute to plaque destabilisation and ruptures by cathepsin B.

Place, publisher, year, edition, pages
Nova Science Publishers, Inc., 2015. Vol. 8, 157-164 p.
National Category
Clinical Medicine
Research subject
Health and Welfare
URN: urn:nbn:se:du-21204ScopusID: 2-s2.0-84958851187ISBN: 978-163482582-5ISBN: 978-163482551-1OAI: oai:DiVA.org:du-21204DiVA: diva2:909050
Available from: 2016-03-04 Created: 2016-03-04 Last updated: 2016-03-04Bibliographically approved

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