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  • 1. Iggman, D
    et al.
    Ärnlöv, Johan
    Dalarna University, School of Education, Health and Social Studies, Medical Science.
    Vessby, B
    Cederholm, T
    Sjögren, P
    Risérus, U
    Adipose tissue fatty acids and insulin sensitivity in elderly men2010In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 53, no 5, p. 850-857Article in journal (Refereed)
    Abstract [en]

    Aims/hypothesis: Dietary fatty acids may affect insulin sensitivity. Adipose tissue fatty acid composition partly reflects long-term dietary intake, but data from large studies regarding relationships with insulin sensitivity are lacking. We aimed to determine the association between adipose tissue fatty acids and insulin sensitivity in elderly Swedish men. Methods In a cross-sectional analysis of the community-based Uppsala Longitudinal Study of Adult Men (n?=?795, mean age 71 years), adipose tissue biopsies were obtained and fatty acid composition was determined by gas–liquid chromatography. Insulin sensitivity was measured directly by a euglycaemic clamp. Results Palmitic acid (16:0), the major saturated fatty acid (SFA) in the diet and in adipose tissue, was negatively correlated with insulin sensitivity (r?=?-0.14), as were 16:1 n-7 (r?=?-0.15), 20:3 n-6 (r?=?-0.31), 20:4 n-6 (r?=?-0.38), 22:4 n-6 (r?=?-0.37) and 22:5 n-3 (r?=?-0.24; p?<?0.001 for all). Some minor SFAs were positively correlated; 12:0 (r?=?0.46), 14:0 (r?=?0.32), 17:0 (r?=?0.21) and 18:0 (r?=?0.41; p?<?0.001 for all), as were essential polyunsaturated fatty acids (PUFAs) 18:2 n-6 (r?=?0.10, p?<?0.01) and 18:3 n-3 (r?=? 0.16, p?<?0.001). Docosahexaenoic acid (22:6 n-3) was negatively correlated (r?=?-0.11, p?<?0.01), whereas eicosapentaenoic acid (20:5 n-3) was not (r?=?-0.02, NS). Most associations diminished or disappeared in lean individuals, indicating an effect of obesity. Conclusions/interpretation Adipose tissue enriched with palmitic acid and depleted of essential PUFAs is associated with insulin resistance. The positive association between minor SFAs and insulin sensitivity merits further investigation.

  • 2.
    Xu, Hong
    et al.
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital K56, Karolinska Institutet, 14186, Stockholm, Sweden ; Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.
    Jia, Ting
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital K56, Karolinska Institutet, 14186, Stockholm, Sweden.
    Huang, Xiaoyan
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital K56, Karolinska Institutet, 14186, Stockholm, Sweden ; Division of Nephrology, Peking University Shenzhen Hospital, Peking University, Shenzhen, China.
    Risérus, Ulf
    Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.
    Cederholm, Tommy
    Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.
    Ärnlöv, Johan
    Dalarna University, School of Education, Health and Social Studies, Medical Science. Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala, Sweden .
    Sjögren, Per
    Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.
    Lindholm, Bengt
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital K56, Karolinska Institutet, 14186, Stockholm, Sweden.
    Carrero, Juan-Jesús
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital K56, Karolinska Institutet, 14186, Stockholm, Sweden ; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
    Dietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men2014In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 57, no 8, p. 1561-1568Article in journal (Refereed)
    Abstract [en]

    AIMS/HYPOTHESIS: We tested the hypothesis that dietary acid load may increase the risk of type 2 diabetes, and studied the association between acid load and insulin sensitivity as a possible mechanism involved.

    METHODS: An observational survey with prospective follow-up including 911 non-diabetic Swedish men aged 70-71 years was carried out. The gold standard euglycaemic-hyperinsulinaemic clamp technique and the OGTT were used to determine insulin sensitivity and beta cell function, respectively. Diabetes incidence was assessed during 18 years of follow-up. Renal function was estimated from serum cystatin C concentrations. Dietary acid load was calculated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) algorithms from 7 day food records. Adequate dietary reporters were identified by Goldberg cut-offs.

    RESULTS: PRAL and NEAP were not associated with insulin sensitivity or beta cell function. Underlying kidney function or consideration of dietary adequate reporters did not modify these null findings. During follow-up, 115 new cases of diabetes were validated. Neither PRAL nor NEAP was associated with diabetes incidence.

    CONCLUSIONS/INTERPRETATION: Our results do not support the hypothesis that dietary acid load influences insulin sensitivity, beta cell function or diabetes risk. Interventional studies modifying acid-base dietary intake are needed to further elucidate a possible role of acid load in the development of type 2 diabetes.

  • 3.
    Ärnlöv, Johan
    et al.
    Dalarna University, School of Education, Health and Social Studies, Medical Science.
    Zethelius, B
    Risérus, U
    Basu, S
    Berne, C
    Vessby, B
    Alfthan, G
    Helmersson, J
    Serum and dietary beta-carotene and alpha-tocopherol and incidence of diabetes in a community based study of Swedish men2009In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 52, no 1, p. 97-105Article in journal (Refereed)
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