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  • 1. Carlsson, Eva
    et al.
    Stålnacke, Katri
    Persenius, Mona
    Olai, Lena
    Dalarna University, School of Education, Health and Social Studies, Caring Science/Nursing.
    Hägg, Mary
    Aspects of eating and quality of care among elderly in short-term accommodations - before and after an intervention.2014Conference paper (Other academic)
  • 2. Lennhed, Björn
    et al.
    Borelius, Charlotta
    Kastemyr, Helen
    Jansson, Lotta
    Olai, Lena
    Dalarna University, School of Education, Health and Social Studies, Caring Science/Nursing.
    Utvärdering av det regionala vårdprogrammet för personer med demenssjukdom2014Report (Other (popular science, discussion, etc.))
  • 3.
    Olai, Lena
    Dalarna University, School of Education, Health and Social Studies, Caring Science/Nursing. Region Dalarna, enheten för Utveckling, hälsa och välfärd.
    Rapport Öppna Jämförelser (ÖJ): Vård och omsorg om äldre i Dalarna 20132014Report (Other (popular science, discussion, etc.))
  • 4.
    Åberg, Anna Cristina
    Dalarna University, School of Education, Health and Social Studies, Medical Science. Uppsala universitet.
    Aktuell geriatrisk forskning i Uppsala2018In: Svensk geriatrik, ISSN 2001-2047, no 2, p. 9-12Article, review/survey (Other academic)
  • 5. Åhman, Hanna Bozkurt
    et al.
    Giedraitis, Vilmantas
    Cedervall, Ylva
    Lennhed, Björn
    Berglund, Lars
    McKee, Kevin
    Dalarna University, School of Education, Health and Social Studies, Social Work.
    Kilander, Lena
    Rosendahl, Erik
    Ingelsson, Martin
    Åberg, Anna Cristina
    Dalarna University, School of Education, Health and Social Studies, Medical Science. Uppsala University.
    Dual-task performance and neurodegeneration: Correlations between timed up-and-go dual-task test outcomes and Alzheimer's disease cerebrospinal fluid biomarkers2019In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Tools to identify individuals at preclinical stages of dementia disorders are needed to enable early interventions. Alterations in dual-task performance have been detected early in progressive neurodegenerative disorders. Hence, dual-task testing may have the potential to screen for cognitive impairment caused by neurodegeneration. Exploring correlations between dual-task performance and biomarkers of neurodegeneration is therefore of interest.

    OBJECTIVE: To investigate correlations between Timed Up-and-Go dual-task (TUGdt) outcomes and Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers amyloid-β 42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau).

    METHODS: This cross-sectional cohort study included 90 participants (age range 49-84 years) undergoing memory assessment, who were subsequently diagnosed with AD, other dementia disorders, mild cognitive impairment, or subjective cognitive impairment. TUG combined with "Naming Animals" (TUGdt NA) and "Months Backwards" (TUGdt MB), respectively, were used to assess dual-task performance. The number of correct words and time taken to complete the tests were measured. The CSF biomarkers were analysed by ELISA. Spearman's rank correlation was used for analyses between TUGdt outcomes (TUGdt NA and TUGdt MB), and CSF biomarkers, adjusted for age, gender, and educational level.

    RESULTS: The number of correct words, as well as the number of correct words/10 s during TUGdt NA correlated negatively to CSF t-tau and p-tau. No correlations were found between any time scores and CSF biomarkers.

    CONCLUSION: The correlations between TUGdt NA and t-tau and p-tau may indicate that neurodegeneration affects dual-task performance. Longitudinal studies are needed to further explore dual-task testing in screening for cognitive impairment due to neurodegeneration.

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