Background: Sexual education (SE) aims to provide young people with knowledge on sexuality and reproductive health to support healthy decision-making. Specifically, Comprehensive Sexuality Education (CSE) teaches skills for forming respectful social and sexual relationships, while emphasising gender equality and promoting safer sexual practices. Aim: The aim of this study is to explore the barriers to the implementation of CSE in a global context. Methodology: The methodology followed the design of a qualitative integrative review, and data were analysed utilising an inductive content analysis. Results: The study reviewed findings from 16 articles representing 14 countries. The barriers identified were related to the local educational systems, the students’ identities, and general attitudes. Within these generic categories, several sub-categories were identified to furtherexplore the barriers to implementing CSE globally. These were found in every level of implementation and were perpetuated by negative stereotypes surrounding sexual education. Conclusion: The present study concluded that power dynamics aimed toward the implementation of CSE are striving for social conformity, with intersecting identities playing a major role in the effect of this power on the members of society.