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Careful selection of construction materials and the efficient management of post-use materials are vital for resource-efficient buildings with lower environmental impacts. This study explores the implications of circular economy practices, entailing efficient post-use materials recovery for reduced environmental impacts of cross-laminated timber (CLT) multi-storey construction. The global warming potential (GWP), acidification potential (AP) and eutrophication potential (EP) of a CLT building are explored in a life cycle perspective, including include all building materials-related activities in the product, construction, end-of-life stages, with a focus on circularity strategies - cascading, reuse, and recycling of post-use building materials. The results show that the building's end-of-life stage represent a significant share of the total life cycle GWP impacts. However, the stage represents a relatively smaller share of the AP and EP impacts. The implementation of circularity significantly reduces the life cycle climate impacts of the building. The end-of-life stage, which represents about 20% of the total material-related GWP impact, can be effectively mitigated through these circularity strategies. Cascading proves to be a better option compared to reuse and recycling, offering a GWP benefit of 70 kgCO<inf>2eq</inf>/m2. Comparatively, the GWP benefit from cascading is 64% and 72% higher than that of the reuse and recycling options, respectively. This study highlights the importance of life cycle perspective and circularity strategies at the end-of-life stage of CLT buildings to reduce environmental impacts. © 2025 Elsevier B.V., All rights reserved.