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Profiling Cognitive Reserve Among Community-Dwelling Older Adults: A Latent Class Analysis
Yale University, Orange, Connecticut, United States, US.
Peking Union Medical College Hospital, Beijing, Beijing, China (People’s Republic), CN.
Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, Beijing, China (People’s Republic), CN.
Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, Beijing, China (People’s Republic), CN.
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2025 (English)In: Innovation in Aging, E-ISSN 2399-5300, Vol. 9, no Supplement_2, p. 1142-1142Article in journal, Meeting abstract (Refereed) Published
Abstract [en]

Cognitive reserve (CR) is a multidimensional construct shaped by education, occupation, and leisure activities, yet traditional scoring approaches obscure heterogeneity among older adults. This study applied latent class analysis (LCA) to identify distinct CR profiles and examine their clinical correlates. A cross-sectional sample of 426 community-dwelling older adults aged ≥65 years in Beijing, China, was assessed using the Cognitive Reserve Index questionnaire (CRIq). Two CR profiles emerged: Class 1, characterized by low reading and leisure engagement (51.9%), and Class 2, defined by higher educational attainment and cognitively demanding occupations (48.1%). Compared with Class 1, Class 2 participants had higher Montreal Cognitive Assessment scores (26 vs. 25, p < 0.001), fewer subjective cognitive decline symptoms (3.5 vs. 4.5, p < 0.001), and lower frailty burden (Fried phenotype score: 0 vs. 1, p = 0.006). Class 2 membership was also associated with better chewing ability (p = 0.004), higher household income (p < 0.001), and greater likelihood of being male (p = 0.007). Age was inversely associated with Class 2 membership (β=–0.060, p = 0.024). These findings reveal meaningful heterogeneity in CR within aging populations and highlight the importance of stratifying older adults by CR profiles. Identifying subgroups at risk for cognitive decline and frailty provides new opportunities for targeted interventions to promote resilience for aging.

Place, publisher, year, edition, pages
2025. Vol. 9, no Supplement_2, p. 1142-1142
National Category
Geriatrics Public Health, Global Health and Social Medicine Gerontology, specialising in Medical and Health Sciences
Identifiers
URN: urn:nbn:se:du-52251DOI: 10.1093/geroni/igaf122.3830OAI: oai:DiVA.org:du-52251DiVA, id: diva2:2025063
Conference
Gerontological Society of America (GSA) Annual Scientific Meeting, November 12-15, 2025, Boston, MA., United States.
Available from: 2026-01-04 Created: 2026-01-04 Last updated: 2026-01-08Bibliographically approved

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Engström, Gabriella

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